ABSTRACT
The objective of this study was to evaluate clinical characteristics, etiology, and resistance to antimicrobial agents, among patients with ventilator-associated pneumonia (VAP). A case study vs. patients control under mechanical ventilation and hospitalized into clinical-surgical adults ICU of HC-UFU was performed from March/2005 to March/2006. Patients under ventilation for over 48 h were included in the study including 84 with diagnosis of VAP, and 191 without VAP (control group). Laboratory diagnosis was carried out through quantitative microbiological evaluation of tracheal aspirate. The identification of pathogens was performed by classical microbiological tests, and the antibiotics sensitivity spectrum was determined through the CLSI technique. VAP incidence rate over 1,000 days of ventilation was 24.59. The mean (± SD) duration of mechanical ventilation prior to VAP diagnosis was 23.2 ± 17.2 days. By multivariate analysis the risk factors predisposing for VAP were: mechanical ventilation time and mechanical ventilation > seven days, tracheostomy and use of > three antibiotics. Mortality rate was high (32.1 percent) but lower than that of the control group (46.5 percent). Major pathogens were identified in most of patients (95.2 percent) and included: Pseudomonas aeruginosa (29 percent), Staphylococcus aureus (26 percent), Enterobacter/Klebsiella/Serratia (19 percent) and Acinetobacter spp. (18 percent), with expressive frequencies of P. aeruginosa (52 percent), S. aureus (65.4 percent) and Enterobacteriaceae (43.7 percent) resistant to imipenem, oxacillin and 3/4 generation cephalosporins, respectively. In conclusion, our observation showed VAPs caused by multiresistant microorganisms, the prescription of > three antibiotics, and mortality with unacceptably high rates. The practice of de-escalation therapy appears to be urgently needed in order to improve the situation.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Gram-Negative Bacteria , Gram-Positive Bacteria , Pneumonia, Bacterial , Pneumonia, Ventilator-Associated , Anti-Bacterial Agents/pharmacology , Brazil/epidemiology , Case-Control Studies , Drug Resistance, Multiple, Bacterial , Gram-Negative Bacteria/classification , Gram-Negative Bacteria/drug effects , Gram-Negative Bacteria/isolation & purification , Gram-Positive Bacteria/classification , Gram-Positive Bacteria/drug effects , Gram-Positive Bacteria/isolation & purification , Hospitals, University , Incidence , Intensive Care Units , Microbial Sensitivity Tests , Pneumonia, Bacterial/epidemiology , Pneumonia, Bacterial/etiology , Pneumonia, Bacterial/microbiology , Pneumonia, Ventilator-Associated/epidemiology , Pneumonia, Ventilator-Associated/etiology , Pneumonia, Ventilator-Associated/microbiology , Risk FactorsABSTRACT
O botulismo constitui uma forma rara de intoxicaçäo alimentar, particularmente em nosso meio. A única epidemia comprovada desta doença no Brasil ocorreu na década de 1950, no Rio Grande do Sul, onde nove pessoas a adquiriram, após a ingestäo de conserva caseira de peixe. O presente estudo relata um surto de Botulismo Tipo A ocorrido em uma família de 8 membros, dos quais 7 contraíram esta toxinfecçäo após a ingestäo de carne suína conservada sob a forma de enlatado caseiro. Duas evoluiram para o óbito, e os restantes recuperaram-se após variável tempo de evoluçäo. Onze meses após, diagnósticou-se novo caso desta doença, cuja fonte da intoxicaçäo näo pôde ser detectada. Pretende-se com esta publicaçäo, divulgar a segunda epidemia comprovada de Botulismo no Brasil, e chamar atençäo para seu quadro clínico, diagnóstico e tratamento, praticamente desconhecidos em nosso meio
Subject(s)
Adolescent , Middle Aged , Humans , Male , Female , Botulism/epidemiology , Food Preservation/adverse effects , Meat/poisoning , Disease Outbreaks/epidemiology , Botulinum Antitoxin/therapeutic use , Botulinum Toxins/blood , Botulism/drug therapy , Brazil , SwineABSTRACT
Os autores apresentam uma experiência de quatro doentes portadores de tumores avançados do esterno, que foram passíveis de resseçäo. O motivo central foi fazer uma revisäo clínico-patológica dos tumores esternais e demonstrar a exeqüibilidade de ressecçöes maiores com reparaçöes à custa de próteses de acrílico ou enxertos ósseos de ilíaco